Pipeline

Molecule

The vaccine candidate is based on a viral vector based technology.

Main indications

Prophylactic protection against a Hepatitis C infection

Molecule

Elafin is a soluble endogenous protein produced by the human body and is a natural inhibitor of the two tissue destroying enzymes, neutrophil elastase and proteinase-3. Both of these enzymes are known to be involved in the inflammatory response occurring in a variety of diseases.

Furthermore, Elafin inactivates an additional enzyme (endogenous vascular elastase), which is involved in inflammatory damage to blood vessels.

Main indications

Elafin is unique due to its human origin, its specificity for the relevant human proteases and its low toxic potential compared with synthetic alternatives.

Due to its broad anti-inflammatory mode of action, Elafin represents a multi indication product.

Clinical developments in esophagus cancer surgery, coronal artery bypass surgery, pulmonary arterial hypertension and kidney transplantation surgery are running or planned.

Molecule

Intermittent administration of recombinant human parathyroid hormone (1–34) (20 μg/day) increases osteoblast formation and inhibit osteoblast apoptosis, which results in an increase in bone turnover and formation. It is the first osteoporosis treatment that leads to the formation of new bone with architecture similar to normal bone. Overall there is a net increase in bone with each PTH cycle, thus reducing the risk of fragility fractures.

Main indications

Treatment of post-menopausal osteoporosis and male/female osteoporosis secondary to hypogonadism, sex steroid deficiency, rheumatoid arthritis, and certain malignancies in which bone resorption occurs in excess of bone formation and the patient is at very high risk for having bone fractures.

Molecule

FVIII is a complex and fragile 300 kDa glycoprotein that plays a crucial role in the human clotting cascade.

Main indications

Hemophilia A is a rare inherited bleeding disorder due to mutation of the gene that encodes the coagulation protein factor VIII.

Recombinant factor VIII is used for replacement therapy. First, to provide sufficient factor VIII to prevent spontaneous bleeding, and second, to provide sufficient factor VIII to have a normal coagulation function after any trauma.

Molecule

Recombinant HSA maintains colloid oncotic pressure and increases circulating plasma volume because the naturally formed human serum albumin is major protein component of human plasma and is responsible for 80% of the colloid osmotic pressure of plasma (25-33 mmHg).

Main indications

rHSA is used as a plasma expander in different disease conditions such as hemorrhagic shock, cirrhosis with ascites, and other critical clinical conditions related to plasma volume and oncotic pressure such as burns, shock and blood loss.

Molecule

Bivalirudin is a specific and reversible direct thrombin inhibitor. It inhibits both circulating and clot-bound thrombin.

Chemically, it is a congener of the naturally occurring drug Hirudin [found in the saliva of the medicinal leech Hirudo medicinalis), but its thrombin inhibition is reversible and it has a shorter half-life than hirudin, reducing herewith the risk of severe bleedings (heparin-induced thrombocytopenia).

Main indications

Anticoagulant for patients undergoing percutaneous coronary interventions (PCI).

Anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA) Anticoagulant to be administered with aspirin and clopidogrel.

Molecule

SAK is a 136-amino acid protein secreted by certain strains of Staphylococcus aureus. It functions as a profibrinolytic agent by virtue of its ability to convert the zymogen human plasminogen (hPg) to its active serine protease form, plasmin (hPm).

Main indications

It is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism.

Molecule

TNF blocker. It works by blocking a protein (TNF-alpha) found in the body that causes inflammation.

Main indications

Treatment of a variety of moderate to severe inflammatory conditions (eg, rheumatoid arthritis, juvenile idiopathic arthritis [JIA], psoriatic arthritis, ankylosing spondylitis).

Molecule

Angiogenesis inhibitor; it works by interfering with the growth and spread of cancer cells in the body, by inhibiting vascular endothelial growth factor A (VEGF-A). VEGF-A is a chemical signal that stimulates angiogenesis in a variety of diseases, especially in cancer.

Main indications

Treatment of metastatic colorectal cancer (mCRC), a type of colon cancer, advanced non squamous non-small cell lung cancer (NSCLC), cervical cancer and recurrent blioblastoma, a type of brain cancer. It is usually given as part of a combination of cancer medicines.

Molecule

It works by attaching itself to the HER2 receptors on the surface of breast cancer cells and blocking them from receiving growth signals. By blocking the signals, it can slow or stop the growth of the breast cancer.

Main indications

Treatment of certain types of breast cancer (HER2 receptor positive).